Sunday, 16 November 2014

Remission & Natto (NSD Book Chapter)

The following is a draft of content which I intend to be added to my NSD Chapter

-- Combatting fungi --

Polygodial 

In 2013 and 2014 I have been quite focused on combatting fungal infections. I tried out a product called Kolorex and in January of 2014 noticed that it helped with the dehydration that I had been experiencing at night. I looked up its active component Polygodial, found that it was an antifungal, and is found in Dorrigo Pepper, Australian Mountain Pepper, Horopito, Canelo, Paracress and Water-pepper. The Maori's of New Zealand traditionally used Horopito to treat fungal infections. Some interesting properties in this compound - it inhibits the ability of pathogens to form attachments to, for instance, your gut wall, bladder etc. 

By chance I found some Australian Mountain Pepper (also containing Polygodial) whilst browsing an Oxfam shop in Sydney. It cost about $10, which I considered pretty cheap as far as experiments are concerned. Worth a shot. I took a little Mountain Pepper and found that when taken on an empty tummy it very quickly cleared my nose (sinus/rhinitis), and Proctitis (itchy bum) cleared quickly too, as did the constant fatigue of my condition. Those three only took about 30 minutes to clear up. I found this remedy worked well if taken on an empty tummy with a glass of juice or water. When taken at dinner I would wake feeling refreshed and well rested - a state that I had become completely unaccustomed to. For so many years I have been waking up feeling tired, lethargic and as sleepy as when I went to bed. 

Another useful property was that Mountain Pepper would clear the dreaded "brain fog" that was so disabling, particularly at work. There was a downside however, it sometimes caused a bit of a headache, but only for a short while (possible die off reaction). 

Is it possible that so many of those little gremlins that are eating away at my quality of life .. that so many of these symptoms are caused by a fungal infection? Sinusitis, proctitis, brain fog, and fatigue, these all cleared after consuming a known anti-fungal, ie. Polygodial from Australian Mountain Pepper. 

After a few weeks of usage of Mountain pepper it seemed to take larger doses to achieve the same result, and after a month or so it just stopped working. Typical.. I have experienced this several times before with other things (Ginko tea, and Bromelain for instance). I expect it will only work again after a long pause in its usage.

Lufenuron

I had read about an interesting compound called Lufenuron a while back - most likely in 2013. In February of 2014 I plucked up the nerve to finally give it a try. The first two days nothing happened of note as it needs to build up in your system until the right concentration is reached. I was taking about a half teaspoon daily and it had to be taken with fatty foods. Typically I used yoghurt or almond butter.. or both all at once. 

On the third day was when things started to happen. My head was very clear, that was nice. However the jock itch I was experience became -worse-. Not only that, but the Proctitis was noticeably worse, there was a burning sensation when peeing, and there was some abdominal pain in the vicinity of the prostate. All very interesting but it didn't phase me at all and I pressed on. This was almost certainly a fungal die off reaction. 

On the fourth day things improved. My head was still very clear and I noted that I could think and make decisions better than previously. The jock itch had calmed down and now there was some skin peeling where it had previously been a bit inflamed. Proctitis was completely cleared, as were the abdominal pains, and prostate. It did burn a bit when urinating still. That afternoon I drank a bit of alcohol and unfortunately that undid much of the good work! Back came some mild proctitis, mild prostatitis, brain fog and also the night dehydration. I think the alcohol only temporarily worsened these issues. About a week later after finishing the course of Lufenuron I made a note that the old problems all seemed to gradually return. So typical. These little gremlins sure are tough to shift. 

Fiji 

In very early May 2014 I was taking Lufenuron again but stopped before going on my holiday to Fiji. I felt it was better if I didn't have to try and explain the product as someone may find a white powder strange or suspicious in some way. Instead I would take my Australian Mountain Pepper with me since it was apparently nothing more than a condiment. Of course it is much more than that to me. 

I was taking my mountain pepper quite regularly during my holiday. The extra energy was most welcome as we went travelling and snorkelling on gorgeous little islands. One island was so small you could walk across it in thirty seconds. The snorkelling was wonderful, the coral were both beautiful and fascinating, and those vibrantly coloured fish!. 

In mid May my fiancé and I were exploring Nadi town and became hungry. We sat down at an Indian restaurant - not a good choice for someone on a No Starch Diet. I ordered something but apparently chose quite poorly.. well, poorly according to my dietary needs. But my senses were telling me otherwise and I did succumb to these. The curry was delicious and couldn't resist!

Here are the notes which I made at the time:

"Ate quite a starchy indian curry yesterday whilst eating out. My partner told me it definitely had besan flour in it to thicken it up, and it reacted immediately to iodine. Decided to try it anyway, "for science!" Hehe. It was just tooo yummy to turn down.
About an hour or two later I started to get very very tired which is a classic symptom for me when eating starch .. But the painful inflammation never came! Looks like the anti fungal compounds I have been taking are keeping this disease at bay!?!"

Natto

This year I had moved into a new flat in Sydney. My neighbours from unit 7 were very kind, they greeted me and asked if we could meet for a chat to which I agreed. Whilst we chatted in my flat they noticed my interest in supplements and quite sensibly realised I had some health problems. When they asked, I mentioned that my condition was very much linked to the health of my digestive system. They were both quite keenly into health, but from a uniquely Korean, or Asian, perspective. They recommended things a westerner might never consider: homemade Natto and Kimchi. 

One day my neighbours made some homemade Natto for me. I tried it on Tuesday night (10 June 2014) and soon posted a photo on my blog. At first I was not noticing much in terms of immediate changes. A few days later I believe my jock itch became a bit more inflamed and then calm down again, this much was similar with what I observed taking Lufenuron. It was that weekend when things became interesting. My fiancé had booked us into a winery tour of Canberra and the surrounding region. There are some really nice ones in the area if you know where to go. For lunch we stopped at the Four Winds Winery. They focus on their wines really, and for food it is just pizza and more pizza. I brought my own food as I had been forewarned of this situation. But wow the pizza looked sooo good! I told my fiancé it would be worthwhile trying starch again and seeing how well I tolerated it. Usual excuse. Lets face it, I have a weakness for good food. My fiancé was a bit wary but I said I would just have a little and see how I went. I suppose that when the only thing you have on the menu is pizza, then it ought to be bloody good pizza.. and they did not disappoint. The pizza was as amazing as it looked and smelled. And did I stop at one slice? Oh noo .. I couldn't stop. So yummy!

When we were back on the bus a few hours after lunch I mentioned I my fiancé that I should have been feeling some symptoms by now.. But I wasn't. For over 10 years I have reacted to starch like clockwork, but not this time. Why didn't I react?. I believe I hadn't yet put two and two together and made the connection with Natto. It may seem obvious with hindsight but my first suspects would have been Lufenuron and Polygodial.

Normally my reaction after a starchy meal shows up within less than 4 hours and then peaks at 24 hours, then gradually subsides over another two days. Three days of pain all up. The only exception is that on very very rare occasions after months of very carefully following a no starch diet I can sometimes get away with some starchy food.. but just once though as after that my immune system is primed again and a full blown reaction will occur. 

I kept taking the Natto for several weeks and noticed that it made my eczema worse, so I decided to stop taking it for a while and let my eczema calm down. It took about a week but the starch sensitivity returned (on 10th July 2014) and AS came with full force after eating some cheap hummus. It wasn't even good hummus. I would put up with some pain for good quality hummus but this it was not. Anyway, I decided to try the Natto again and lo and behold the AS calmed down within 24 hours of consuming Natto. Not bad eh. So that was it then, the Natto was surely the thing which had brought me into remission this time, although it didn't explain my experience in Fiji. Why didn't I go into full blown inflammation, as I should have, when eating that starchy curry in Fiji? Was it the Lufenuron or the Mountain Pepper, or perhaps both?
Bacillus Subtilis is a very very closely related strain to Bacillus Natto which is found in commercial Natto. It just so happens that Bacillus Subtilis is a popular alternative remedy for fungal problems. This is the one common thread I can see, both in my observations in Fiji and now with Natto - in both cases we see an anti-fungal at the heart of my remission. 
I asked my neighbour how she makes her Natto .. and she doesn't add any starter culture. So it is quite possible that wild Bacillus Subtilis strains have entered their Natto culture. Wild Bacillus Subtilis is found in soil and is an extremophile, which means it tolerates very extreme conditions. You can boil this one and its spores can still survive! The B. Subtilis culture could even be originating from the soy beans themselves.



Returning home to starchville

Now that I could eat starch again I went thoroughly overboard. Several kind hearted souls mention their concern for my sudden eagerness to jump in the deep-end of starch consumption. It was certainly testament to my lack of will power, but I wanted to try everything. All these starchy foods such as croissants, Vietnamese pork rolls, potato wedges, porridge .. All these many foods had been forbidden me for over ten years. Can you imagine not bring able to eat chocolate for ten years?

Observations about resuming starch

After a while I calmed down as I gradually started to take note of which starches were best for me. For instance deep fried starch as found in batter or doughnuts and the like can still cause me mild AS symptoms. This inflammation however is far far milder than the usual reaction, less than a tenth of the usual starch reaction. What's more the reaction is not only quite mild, but also short lived and always dissipates by the next morning. On several occasions certain foods (for instance cheese) caused my starch sensitivity to briefly return. Initially I had thought that I needed to keep eating Natto in order to keep my A.S. in remission, but it gradually became clear that this was not the case, and that the remission would always return. 

I tried eating normal rice, and even basmati rice, but both very reliably bring on quite severe proctitis, just as with glutinous rice. All those years ago when I first started cutting out grains I had kept rice until last. Well now I know why I had so much difficulty with proctitis and yeast infections at that time. How strange it is now to find that wheat, my mortal nemesis, is now my kind friend and rice now shunned. How the tables have turned. 

Sugar, in the form of sucrose, still poses a real threat to me. When I eat foods that are adulterated with refined sugar I experience pain in the region of my prostate & bladder. I also can experience proctitis and a strange dehydration that seems exactly like Sjögren's syndrome and which inexplicably worsens greatly when I sleep, followed by fatigue and weakness. 

I'm unsure at the moment but I fear the same problems as found in sucrose may also be found with very high glycemic loads such as with white bread? I reacted badly to a Vietnamese pork bun, however it is quite inconclusive since the sauces they use certainly do contain refined sucrose. I have some doubts though, since pasta and wholemeal bread are quite safe thus far. Well, I certainly do find that the same wheat starch can digest quite differently depending on how it is prepared - deep fried versus steamed, al dente versus over cooked, or fluffy white bread versus a denser wholemeal or rye bread. 

Whilst following the NSD a cavity in a molar on the lower right side of my jaw had healed to some extent. It lay dormant as long as I stayed away from dried fruits and excess of sweets such as chocolate. But upon eating starch (including amylopectin starch) I found that this cavity would become a problem again, and I must now be far more vigilant about dental hygiene. Weston Price would have much to say on this, I have no doubt (if he were still alive). 

My eczema has also returned once I resumed eating starch. It isn't too severe though, and I find that apple cider vinegar helps (both oral and topical) and 500mg of vitamin B3 also brings relief (taken orally, and this too can be used topically if you wish). But I have dwelled far too much on the negative aspects of starch thus far. Time for some positive words..

Eating starch again has made life so much easier, I now have far more energy and not nearly as prone to debilitating bouts of fatigue. My body temperature is very noticeably warmer, something I believe my fiancé may have first noticed when holding my hand. Normally I was significantly colder than her, whereas now I am noticeably warmer and tolerate cold weather much better. 

I had difficulty getting the energy I needed whilst following the NSD. Unfortunately my body never adapted well to burning fat as fuel. In fact fats from fatty food I ate would regularly be seen floating as an oil slick after going to the toilet. This inability to assimilate and make use of fat as fuel makes me a rather poor poster child for the NSD and it is not my desire to dissuade others from following it, but rather to be realistic about its benefits and shortcomings. An inability to assimilate fat doesn't seem to be common, and yet I'm certainly not the only person as I can think of one other who complained of this issue. He found that he needed some starch to help digest, or "bind" the fats in our food. Coconut oil is an exception here, as even my body finds this an acceptable fuel at most times. 

Now that energy levels had normalised I was also starting to gain weight, a situation I was quite happy with as I was a tad too skinny before. After putting on about 5 kilos my weight stabilised nicely. 

There seemed to be noticeably less muscular tension. For the most part I attribute this to eating less animal fat. A heresy for those following a Paleo-diet of course that I should say so, but too much animal fat was a problem for me. To each their own. 

I don't regret following the NSD, as it was what my body needed at that time. Without the NSD my disorder will have continued its course of degeneration and calcification of my major joints. And let's not forget the years of great physical pain that I have been spared. For this I have much to thank those at the kickas.org forum, and perhaps a little thanks should go to the indomitable spirit and the kindness of strangers. 

“There is in this world no such force as the force of a man determined to rise. The human soul cannot be chained” - W.E.B. DuBois

Friday, 14 November 2014

Probiotics. Good and Bad.


Us folk with autoimmune disorder almost always have some kind of dysbiosis - an imbalance in the flora of our gut. For instance, just as an example of the gut-immune connection, gut disorders like Crohn's disease and Ulcerative Colitis are both associated with Ankylosing Spondylitis. Also, taking antibiotics can bring autoimmune symptoms into remission briefly.. although the flora adapt quite quickly, especially the pathogenic ones. 

We are certainly missing key flora necessary for good health (called commensal flora). People have been brought into remission for months at a time via Faecal Matter Transplants (FMT). And I myself experienced an amazing remission of my Ankylosing Spondylitis after my neighbours gave me their homemade Natto. 

But that doesn't mean Yoghurt will help you much. It is beneficial in that it crowds out pathogens and corrects pH (acid producing flora are beneficial). Unfortunately beyond this, the standard probiotics don't do much. They just don't correct the underlying gut disorder, leaky gut or missing commensal flora. 

Some of us have experimented with more exotic probiotics - those with 10 or more strains. I can't get these in Australia so I have to order them online. 

There are a few things to be wary of with probiotics

Our experience as a group (on kickas.org) with probiotics are hit and miss. Worthwhile experimenting with though..But be warned!.. Two members have actually had there AS become worse after taking probiotics. One had a stiff neck for the duration, and the other had his AS badly worsened for some weeks afterwards. Both these people were seasoned followers of the No Starch Diet, and knew to check for starch. 

Starchy additives are quite a common issue we face, as are other polysaccharides used as probiotics, namely inulin and FOS. So watch out for these. 

The other possibility is that the immune system is cross reacting with the flora (think "reactive arthritis" or "molecular mimicry"), especially when the gut lining integrity is poor (leaky gut). When flora get past the gut wall and into our blood stream out immune system will become highly irritated. 

More likely the new flora stimulated their immune system, thus causing the existing immune disorder to worsen. 
This immune stimulation with the flora is what I believe may have happened to the two seasoned NSD followers mentioned earlier. It is fairly rare for this to happen, but I just want people to be aware of this possibility.




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- gut disease and yeast
Antibodies against S. cerevisiae are found in 60–70% of patients with Crohn's disease and 10–15% of patients with ulcerative colitis (and 8% of healthy controls).[2]

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Anti-Saccharomyces cerevisiae antibodies (ASCAs) have been proposed as serological markers, which may differentiate Crohn's disease (CD) from ulcerative colitis (UC) and predict disease phenotype. Their importance in pathogenesis is unproven. We investigated the relationship between ASCAs, disease phenotype and NOD2/CARD15 genotype in CD and whether ASCAs were related to antibodies to other fungal proteins. Serum from 228 patients [143 CD, 75 UC, 10 with indeterminate colitis (IC)] and 78 healthy controls (HC) were assayed for ASCA. Antibodies (IgA, IgG) to other fungal proteins (Fusarium species ATC20334, Mycoprotein) were measured in the same samples using an in-house enzyme-linked immunosorbent assay (ELISA) assay. ASCAs were present in 57% of CD, 19% of UC, 30% of IC and 8% of HCs. ASCA-positive status was a predictor for CD with sensitivity of 57%, specificity of 87%, positive predictive value of 78% and negative predictive value of 68%. ASCA was associated with proximal (gastroduodenal and small bowel involvement) rather than purely colonic disease (P < 0·001) and with a more severe disease phenotype and requirement for surgery over a median follow-up time of 9 years (P < 0·0001). No associations with NOD2/CARD15 mutations were seen. There was no association between ASCA and antibodies to MP (IgA or IgG). These data implicate ASCA as a specific marker of disease location and progression in CD, emphasizing the heterogeneity within IBD.

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Sunday, 2 November 2014

Dairy - study shows potential health risks

I am interested in this study given that many people who suffer from ankylosing spondylitis found that unfermented milk contributed significantly to inflammation.

Summary of points raised by this research:

  • Milk (non-fermented) worsens oxidative stress and inflammation
  • Fermented milk (sour milk and yoghurt) reduces oxidative stress and inflammation
  • Drinking unfermented milk did not reduce the risk of fractures - in fact the reverse was observed!
  • D-Galactose is highlighted as a possible explanation for the health differences between fermented milk and non-fermented milk. Unfermented milk is a major dietary source of D-Galactose. Galactose has been shown in animals to accelerate ageing and worsen oxidative stress.
My personal opinion is that there are differences in how fermented/unfermented milk digests in the gut / feeds harmful/beneficial flora, and that this is more likely the cause, especially given the changes observed in the immune system.



Milk intake and risk of mortality and fractures in women and men: cohort studies
BMJ 2014; 349 doi: http://dx.doi.org/10.1136/bmj.g6015 (Published 28 October 2014)

Abstract
Objective:
To examine whether high milk consumption is associated with mortality and fractures in women and men.
Design:
Cohort studies.
Setting: Three counties in central Sweden.
Participants: Two large Swedish cohorts, one with 61,433 women (39-74 years at baseline 1987-90) and one with 45,339 men (45-79 years at baseline 1997), were administered food frequency questionnaires. The women responded to a second food frequency questionnaire in 1997.
Main outcome measure:
Multivariable survival models were applied to determine the association between milk consumption and time to mortality or fracture.
Results:
During a mean follow-up of 20.1 years, 15 541 women died and 17 252 had a fracture, of whom 4259 had a hip fracture. In the male cohort with a mean follow-up of 11.2 years, 10 112 men died and 5066 had a fracture, with 1166 hip fracture cases. In women the adjusted mortality hazard ratio for three or more glasses of milk a day compared with less than one glass a day was 1.93 (95% confidence interval 1.80 to 2.06). For every glass of milk, the adjusted hazard ratio of all cause mortality was 1.15 (1.13 to 1.17) in women and 1.03 (1.01 to 1.04) in men. For every glass of milk in women no reduction was observed in fracture risk with higher milk consumption for any fracture (1.02, 1.00 to 1.04) or for hip fracture (1.09, 1.05 to 1.13). The corresponding adjusted hazard ratios in men were 1.01 (0.99 to 1.03) and 1.03 (0.99 to 1.07). In subsamples of two additional cohorts, one in males and one in females, a positive association was seen between milk intake and both urine 8-iso-PGF2α (a biomarker of oxidative stress) and serum interleukin 6 (a main inflammatory biomarker).

[following are some quotes from the body of the full text article]

Conclusions:
High milk intake was associated with higher mortality in one cohort of women and in another cohort of men, and with higher fracture incidence in women. Given the observational study designs with the inherent possibility of residual confounding and reverse causation phenomena, a cautious interpretation of the results is recommended.
[...]

Biomarkers
D-galactose supplementation in animals has been shown to increase oxidative stress and inflammation.4 5 6 7 To assess the association between milk intake and biological markers of oxidative stress and inflammation
[...]
Milk intake, oxidative stress, and inflammation

We further investigated whether milk intake was associated with oxidative stress and inflammation. Milk intake was positively associated with 8-iso-PGF2α in both sexes, and with interleukin 6 in men (fig 4⇓). Consumption of fermented milk products (soured milk and yogurt) indicated a negative relation with both the oxidative stress and the inflammatory markers (see supplementary figure C, panel A). No such association was observed with cheese intake (see supplementary figure C, panel B). Milk intake and risk of mortality and fractures in women and men: cohort studies

Results
[...] In women, higher rates were observed for death from all causes (adjusted hazard ratio 1.15, 95% confidence interval 1.13 to 1.17, for each glass of milk), cardiovascular disease (1.15, 1.12 to 1.19, for each glass of milk), and cancer (1.07, 1.02 to 1.11, for each glass of milk) (table 2 and fig 3⇓). Milk consumption corresponding to three or more glasses of milk a day (mean 680 g a day) compared with less than one glass a day (mean 60 g a day), was associated with a hazard ratio of total mortality of 1.93 (1.80 to 2.06) in women, with approximately similar estimates for cardiovascular mortality and somewhat lower for cancer mortality (1.44, 1.23 to 1.69). For women who consumed three or more glasses of milk a day the hazard ratio for any fracture was 1.16 (1.08 to 1.25) and for hip fracture was 1.60 (1.39 to 1.84).

[...]

Comparing milk with other dairy products
Particularly noteworthy is that intake of fermented milk products such as yogurt and soured milk and cheese were associated with lower rates of fracture and mortality. Furthermore, we observed a positive association only between milk intake and markers of oxidative stress (urine 8-iso-PGF2α) and inflammation (serum interleukin 6). Previously, we found a negative relation between bone mineral density and 8-iso-PGF2α.42 63 Interleukin 6 seems to be causally related to cardiovascular disease64 and may influence bone loss and osteoporosis.65 Importantly, those who consume high amounts of non-fermented milk have a more non-favourable cardiovascular risk factor profile, with higher blood pressure, lower high density lipoprotein cholesterol levels, and higher insulin resistance.18 In contrast, intake of cheese and fermented milk products is related to higher high density lipoprotein cholesterol levels, less insulin resistance, and a lower risk of myocardial infarction.18 22 23 24 In addition, a recent small randomised cross over study indicated that the intake of a fermented dairy diet seemed to provide a more favourable biomarker profile than that of a non-fermented dairy diet.66

Potential mechanism
One potential candidate for the discrepant results for different types of dairy products is D-galactose content. The intake of D-galactose from non-fermented milk is considerably higher than that from other food sources, including cheese and fermented milk products. Non-dairy sources of D-galactose are mainly cereals, vegetables, and fruits,67 but the concentration of galactose and the amount ingested from these sources accounts for a small proportion of the total intake of galactose. Put into perspective, the amount of lactose in one glass of milk corresponds to approximately 5 g of galactose, whereas the amount in 100 g of fruits or vegetables67 is measured in milligrams or tens of milligrams. D-galactose given to laboratory animals (mice, rats, and drosophila flies) is an established experimental model for premature aging, including shortened life span caused by oxidative stress and chronic inflammation,4 5 6 7 but whether this mechanism can be generalised to humans needs further scientific support. However, galactosaemia is a genetic disorder that results from loss of galactose-1P-uridylyltransferase, with accumulation of galactose in blood and other tissues as a consequence.68 69 Affected infants experience a rapid escalation of potentially lethal acute symptoms after exposure to milk, and experimental models display oxidative stress as a mechanism for the development of disease.68 Even with dietary restrictions of galactose intake these patients have higher circulating levels of galactose and an increased risk for chronic diseases in adulthood,69 including osteoporosis.70

Conclusion
A higher consumption of milk in women and men is not accompanied by a lower risk of fracture and instead may be associated with a higher rate of death. Consequently, there may be a link between the lactose and galactose content of milk and risk as suggested in our hypothesis, although causality needs be tested using experimental study designs. Our results may question the validity of recommendations to consume high amounts of milk to prevent fragility fractures.3 71 72 The results should, however, be interpreted cautiously given the observational design of our study. The findings merit independent replication before they can be used for dietary recommendations.


Friday, 17 October 2014

Iodine Tests - Konnyaku Noodle - SAFE!

Today I tested out some Konnyaku noodles. As you can see, very little reaction. About the same amount as, say, a cucumber. This brand probably isn't the best quality as there were some small specks of starch. Not enough starch to be a problem for most people following the NSD. Safer than almonds with skin on (yes the skins have a little starch)


Many of these products coming from China are terribly confused about the contents of their own products. Below we have another packet of Konnyaku that is labelled incorrectly as "Pice Vermicelli". No pice in this, nor is there any rice either. 
Above is the front, and below is the back of the same package. Yes indeed, this is Konnyaku noodle. There is no rice at all. I have seen other products incorrectly labelled as containing yam. A quick iodine test tells the truth. 

Amylopectin - Background for NSD Book Chapter

Here is what I wrote about my experiences with eating Amylopectin. I put this together whilst on a bus to Canberra. There are far fewer distractions for me on a bus, my worst enemies happen to be the TV and computer games. But on the bus I simply put my headphones on, listen to some music that I love, and the words come easily (after about an hour of settling in).  


-- Adaptation --
Sometime around late 2007 I found I could adapt to some problem foods. For example, I was not able to eat onions or garlic due to inulin content. Improper fermentation in my stomach was causing inflammation.  I also had issues with linseed [probably due to lignan or dietary fibre]. However after gradually adding the foods back into my diet, first starting with very small amounts, I found that I could gradually adapt to the foods. Soon they caused caused no trouble at all. 

-- Sticky Rice --
One day whilst eating at a Thai restaurant I just couldn't resist trying a little black sticky rice. It's one of those things I used to really really love eating. Even though it was just one or two teaspoons full, I should have reacted.. Well, I would have if this was normal rice. Months passed and eventually I again remembered my love for Thai black sticky rice. This time, remembering my last encounter, I was much more brave and ate quite a decent amount. Still no reaction! What on earth was happening?! 

In late 2011, around November and December, I noticed that sticky rice didn't react to iodine in the same way as normal rice. A did a bit of reading and found that the starch in sticky rice (glutinous rice) is quite different to that which is found in other starchy foods. 

[A little science - There are two main types of starch: amylose starch and amylopectin starch. Amylose reacts to iodine by turning an inky blue-black, and amylopectin instead turns a much lighter brownish colour.  Most starchy foods contain amylose, or a mix of both amylose and amylopectin. It is however quite unusual for a food to have only amylopectin. Glutinous rice is the most easily an cheaply acquired source of amylopectin. Oh and one more thing, the "glutin" in glutinous rice is so named due to its sticky consistency and is in no way related to the "gluten" found in wheat. ]

-- the good --
Throughout 2012 I began to eat glutinous rice quite regularly. I found it had some useful qualities - if I mixed glutinous rice flour with egg to make a pancake then it provided me with a great source of energy to last throughout the day. It was also a useful way for me to put on some weight - a good thing in my case. 

-- the bad --
It may sound counterintuitive but when eating sticky rice, not as a pancake but as a rice, this made me quite sleepy and also significantly worsened my Proctitis. Different quantities of starch are involved and also it digests quite differently when eaten as rice (as opposed to when making pancakes). Plain sticky rice has a very very high glycemic index and the huge rush of blood sugar spikes insulin levels, this then leads to a subsequent blood sugar crash - and this is where I become extremely sleepy and find it difficult to concentrate or do my work. 

-- the ugly --
[Warning: Betty also tried glutinous rice flour and at first all things went fine and well. One day she made a pizza out of glutinous rice flour and then the AS inflammation hit her with full force! So, given both of us having negative experiences I must urge others to be very careful with this and eat it sparingly, and certainly not daily]

Later in 2012, after long indulging in regular glutinous rice flour pancakes I succumbed to the Candida beast. This is one tough demon to battle with. The skin infection was terrible, and amylopectin was without question the cause. 

I tried eating lots of yoghurt and coconut oil to no avail. The creams from the pharmacist were particularly poor. Within a matter of days the fungus would adapt and render the cream ineffective. I would then try another, and yet another and each time the result was the same - they worked in the short term only and provided no lasting cure. 

I then tried methylene blue (orally mixed with Berocca to mask the bitterness) and that helped only with the skin infections. Curiously I found Candida was completely unable to adapt to methylene blue even over a period of many months. Unfortunately methylene blue doesn't really seem to kill Candida directly, instead it puts it in a dormant state where it causes no trouble. Still, it was very useful I'm bringing this beast under control. 

Starving Candida is one option, but that would half-starve me too and takes many months. This route would require an NSD regime that was very low on refined sucrose. 

In early 2014, still struggling with smouldering Candida fungal infections, out of frustration and exasperation I decided to bite the bullet and try Lufenuron. It worked well for the duration that I took it, although it still was not the permanent solution I was hoping for. It seems my body is unusually prone to fungal infections. Dang. 

-- notes --
* Proctitis - sticky rice worsens it, but glutinous rice flour pancakes do not worsen this. Due to digestion (gut flora) or glycemic index. Amylose is mildly protective. Both amylose and amylopectin are prebiotic. 
* Betty Rawker gave glutinous rice a try. At first things went fine and she didn't react but later had a major major reaction after making a pizza using glutinous rice flour. 
* Ted La Monty mentioned Amylopectin way back in March 2004!


-- refs --
Amylopectin - 2011-12 where I first realised amylopectin was safe
http://www.kickas.org/ubbthreads/ubbthreads.php?ubb=showflat&Number=456249&page=2

Amylopectin - the Good, the Bad and the Candida. Nov 2012
http://www.kickas.org/ubbthreads/ubbthreads.php?ubb=showflat&Number=481153

Tuesday, 14 October 2014

Fruit Fast & Feeling Fantastic

I have been doing a "fruit fast" for the last three days. Eating just fruit, and also a few nuts in the morning to help absorb a supplement. But mostly just fresh fruit - apples, mandarins, blueberries, and strawberries. I have sooo much energy now. Feeling amazing. Now I know what Annette Larkins means. Annette says she has so much energy, if she could bottle it and sell it she would be rich.

I will call it a fast just for convenience, technically it is a "partial fast". There are actually many ways of fasting, it doesn't just mean abstinence from all food and drink which is called an "absolute fast". 

Walking through the food court. Mannnnn it is so freakin' tempting. Fatty foods and meats are a hundred times more desirable when abstaining. And my sense of smell is more than ten times as acute. I can taste the subtle flavours in my blueberries. Something that was lost on me before. 





Monday, 13 October 2014

Natural Remedies for Cystitis / Urinary Tract Infections (UTI)


A relative of mine has a chronic urinary infection at the moment and the antibiotics thus far have not worked well at all so I have put this together for her.

Firstly some background.
The pathogens that cause Urinary Tract Infections (UTI / Cystitis) are sensitive to pH, and fortunately this is something that we can change quite easily. So pH really matters.

When we eat acidic foods it doesn't automatically mean that it will make our urine more acidic, for instance citrus fruits will make the urine more alkaline despite being acidic. What happens here is that our body is stimulated to produce more bicarbonates as a response (particularly the pancreas), and also the types of minerals found in fruits are easily converted by our body into bicarbonates. The vast majority of fruit and vegetables will have an alkaline renal load, and this means that it makes our urine more alkaline.

== pH Change ==
We can expect that most UTI microbes will prefer a slightly acid urine, whilst some may prefer it slightly alkaline. None will like a strong alkaline or strongly acidic environment. And in particular the pathogens will not deal well with big swings in pH. That is, if you change the pH from strongly acidic to strongly alkaline within a few hours then they won't be able to tolerate the change. When you acidify the urine it might burn more as it irritates the pre-existing inflammation, so it is a bit tricky to tell if that is helping.

All said though, I suspect the majority cases will benefit quickly from a strongly alkaline urine. The reason is simple, the vast majority of people follow a diet that has an acidic renal load (that acidifies the urine), and thus the pathogens living in their bladder or urinary tract are naturally going to be acid loving. BUT, and this is an important reminder, the pathogens will only tolerate a certain level of acidity. If we make the urine too acidic then even so called "acid loving" pathogens will die.

You can buy pH strips from a pharmacist to test the urine pH. This is a simple tool to help you know whether you are on the right track or not.


== Cream of Tartar (CoT) ==
This is actually a very old and time tested remedy. I would use this first off before all other remedies. How to take it: In juice add a quarter of a teaspoon (preferably no more than a teaspoon in a day). Adding a bit of fresh lemon or lime juice may also improve this remedy.

I had a bit of difficulty working out whether CoT alkalises or acidifies the urine. Ural is a product you can buy at a pharmacy for UTI. The reaction in Ural's ingredients actually produce a very similar compound (ie. a salt of tartaric acid, although Cream of Tartar has more potassium). Ural makes the urine more alkaline and so I believe Cream of Tartar alkalises the pH too.


== Apple Cider Vinegar (ACV) ==
At first this (apparently) acidifies the urine, but over a few days the body compensates and the urine becomes more alkaline. Another popular remedy. Should work well, especially over the first two days. Add a tablespoon or two to a glass of juice.


== Baking Soda ==
1 heaped teaspoon in a glass of water. Must be taken on an empty stomach without any other food / juice etc (it reacts with acids). This will make the urine more alkaline. Best to do this when not hungry. I make a big cup of this and put it near my bed, then drink it first thing in the morning, or when I wake.


== Berries ==
Different berries help in different ways.. particularly Blueberries, Cranberries. I suggest eating a variety of berries.. oh and Cherries too (even if they aren't berries). My suggestion - see if you can find some unsweetened cherry juice, or eat fresh berries, or put some frozen berries in the blender along with a pear to make a smoothie, but please don't add dairy or yoghurt to this as it will negate the benefits.


== Cranberry ==
This contains D-Mannose which inhibits the ability for pathogens to bind to the bladder wall. They end up getting flushed out. You can use cranberry juice or dried cranberry for this, and it is also possible to buy the key compound D-Mannose online. Most cranberry products unfortunately contain a lot of added sugar, which is not good for your immune system.. this added sugar will also likely make the urine pH more acidic.


== Alkalising ==
The following make the urine more alkaline:
  • Cream of Tartar - eighth tsp in fruit juice
  • Ural
  • Fruit
  • Vegetables
  • Fresh fruit juice
  • Vegetable juice
  • Bicarbonate - see directions (above)
  • Tofu - one of few high protein foods that doesn't produce very acidic urine.



== Acidifying ==
The following make the urine more acidic:
  • Coffee
  • Cheese, Yoghurt
  • Eggs (runny)
  • Chicken
  • All meats
  • ACV - acid, then alkaline after two or more days
  • Uroquid - Sodium acid phosphate (Urinary acidifier)




-- More reading --

A table of renal acidifying / alkalising foods. A few items seem misplaced to me, but overall a good guide.
http://preventdisease.com/fitness/nutrition/articles/acid_base_chart.shtml

Good reviews of different natural remedies. Lots of great safe & simple things to try here.
http://everydayroots.com/uti-remedies
http://www.healthextremist.com/natural-remedies-for-uti/

Ted from Bangkok, as usual, wrote a very interesting post here:
http://forums.welltrainedmind.com/topic/153988-can-somebody-explain-why-braggs-apple-cider-vinegar-is-alkalizing-and-not/


EarthClinic typically has good ideas for beating disease. The second link is for pets, but still interesting!
http://www.earthclinic.com/cures/bladder_infection.html
http://www.earthclinic.com/pets/cystitis.html#acv

Some forum chatter on using CoT and D-Mannose / Cranberry for UTI


Monday, 22 September 2014

On Fasting


I used fruit fasts in the early days when I started experimenting with the No Starch Diet. Fruit fasts (or to be more precise, fruit mono-diets) worked wonderfully for me. By the 3rd or 4th day I would be completely pain free without the need of any medication. Normally I would just drink water and eat pears, grapes, apples, and maybe some orange or mandarin too.

Citrus fruits should only be had in moderation whilst on a fast from my experience, whereas pears and grapes could be eaten without restriction. Unfortunately apples will need to be tested for starch using iodine tincture as some farmers like to pick them whilst still a bit unripe, this is particularly true for fruits that are not in season.

Doing fruit fasts really helped me to understand the diet and reinforced the diet --> inflammation link. Afterwards, on eating normal food again, it was also useful to plan what foods I wanted to try first as any reactions / changes in my body would be very informative post-fast

Thursday, 11 September 2014

Making of Natto


My neighbour said that she doesn't add anything at all to it in terms of culture. The soybeans are of course boiled and then strained (possibly by hand, in which case flora could arrive from her body). The beans are then placed in a special device (I don't know what to call it, looks a bit like a rice cooker, lets call it an incubator for now) which she brought from Korea that keeps the beans at a stable temperature between 35-40c. It is left to incubate over a few days.. 2-3 days I think she said. 

Actually B Subtilis is an extemophile and its spores can very easily survive being boiled, so it is quite possible that the culture is still present on the beans and in her incubator. 

I don't know if I could possibly ask her if it touches her hand when she strains the beans - she is an elderly Korean lady, and it might offend or cause too much embarrassment (?). But perhaps I can ask her husband after explaining why I need to know..

Friday, 5 September 2014

Mycotoxins :: The Fungal Connection

I was discussing this with another friend and thought I should share it here:

So many of my little health problems are turning out to be fungal related (and that includes Candida). From my notes the following improved whilst taking an anti-fungal :
 Prostatitis, Proctitis, night dehydration, sinusitis, brain fog, coordination, hand writing, energy levels / stamina, and jock itch

Mycotoxins 
The majority of these problems will be due to mycotoxins - which are incredibly potent poisons. Alkaline salts (calcium carbonate, baking soda) disable 90-94% of these toxins when added to corn [ http://en.m.wikipedia.org/wiki/Nixtamalization ]. 

One very simple way to disable these toxins is to drink bicarb - half a tsp of baking soda mixed in a cup of water. Must be drunk on an empty tummy when there is no hunger otherwise it will react to what is in your stomach and become a useless salt. A good time to drink it is in the middle of the night or first thing in the mining. 

Lufenuron
Taking Lufenuron has been a highly informative exercise.. It was ok as a short term solution to fungal issues but I don't want to use it long term. Baruch recommended a probiotic called Prescript Assist for my Proctitis and that is working nicely - but I need to take quite a lot and it is expensive. Also it appears to be helping my night dehydration too. Good flora killing off & crowding out the fungus. Again it all comes back to body flora. 

Remission revisitted -:- Natto, or is it?


Hi guys,

Here to share something important about my Ankylosing Spondylitis remission.

The following was originally posted by me on kickas.org:

I can still eat starch without issues. There have been a few moments where a teeny bit of inflammation crept in - peanuts are one thing that come to mind here. But each time the very modest amount of inflammation would be gone by the morning.

My neighbours are very kind, and keep me well supplied with Natto.

-- Is it B. Subtilis? Or maybe something else? --
My neighbour has an unusual way of making her Natto - she doesn't add any culture at all. Bacteria will be getting into the soybeans from her skin, the environment, and possibly her breath. So there is no guarantee that this is in fact Bacillus Subtilis that is keeping my condition at bay, it could be some other flora from her or from the environment..  B. Subtilis is a super tough critter though, and should be quite ubiquitous in the environment (it is found in soil) so I still think it is highly likely to be the beneficial species.

With all that in mind, I made sure to freeze samples of her Natto - just in case.

Tuesday, 2 September 2014

Dehydration at Night

This problem, in my case, is almost certainly caused by a fungal infection. This became evident when taking Lufenuron stopped this problem for the duration of treatment. I have had this problem for so many years! It is a very difficult microbe to get rid of, probably living in some hard to reach recess of my body ... maybe in the gut.



-- Helps ease symptoms: --


  • Prescript Assist (very effective). Thanks Baruch for putting me onto this! There are sure to be other probiotics that help, but so far this is the only one I know of for certain.
  • Apple Cider Vinegar (very effective). Use 2tbsp mixed with water. I need to rinse my mouth with mouthwash before hand though as the acidity hurts my teeth even when diluted. Aldi brand mouth wash works fine.
  • Fruit fast (effective)
  • Turmeric? (maybe?)- need to take quite a lot (6-8 pills). I make my own pills using the raw spice.
  • Water flush (moderately effective). Drink 2 or 3 cups of water on an empty tummy.
  • Massaman curry (somewhat effective).. Worked well for 3-4wks, only worked whilst it had a laxative effect.
  • ++ Rest. Lots of sleep and rest. Don't watch late TV or read late at night. Avoid stressing (esp at work). Light physical exercise but not to exhaustion.
  • Lufenuron (seemed effective) - an antifungal
  • Laxative. Try Epsom salts
  • 1tbs cumin +3xStrength ginger tea
  • raw juice - pineapple apple ginger beetroot (celery carrot)
  • Polygodial ? (Mountain Pepper) - I suspect this was helping due to antifungal properties. I use half tsp or more followed by water. Problem is this remedy only works in the short term (maybe 3 weeks or so).


-- Worsens symptoms: --

  • Tired / Going to sleep too late (significant problem). Weakens immune system / liver?
  • High Glycemic Index Foods - Jasmine rice for example
  • Cheese
  • Yeast products 
  • Vinegar (except  for ACV)
  • Preservatives. 220 & maybe Benzoates too. Herx reaction?
  • Alcohol /preservative 220/yeast (champagne & sweet wines are high in preservatives). worse in 30-60min

Thread
http://www.kickas.org/ubbthreads/ubbthreads.php?ubb=showflat&Number=502832


Monday, 18 August 2014

Natto - where to find it



Firstly, Why Natto?
Well if you look back through my old posts here and on kickas.org you will see that Natto brought my Ankylosing Spondylitis into remission. A truly amazing feat for such a humble food. Natto is a Japanese dish made by fermenting soy beans with B. Subtilis, and it is this microbe that has my interest.

A Japanese Person
The first person to ask would be any Japanese friends or colleagues that you may know. They should be clued in on where to get Natto in your area.

Asian Grocery Stores
I asked a Japanese friend if they knew where to buy Natto in Sydney and here is their response:
Image Source: blog.japancentre.com
Everywhere! You will find it in the frozen section on asian grocery stores, sold in bundles of stacked little white styrofoam packages. I defrost them, smother it in heaps of soy sauce and eat over hot rice, wrapped in lots of seaweed. Sadly, I'm the only one who appreciates natto in our house so I don't get to eat it as much. 
If you are going through the city, there is a Japanese grocery store called Maruyu directly behind the cinemas along Kent St, closer to the Liverpool St end. You would also find them in Chinatown, and if you move to Kogarah [..]- there is a shop opposite St George Hospital Emergency. [..] 


Online
I was able to buy Natto starter culture (natto-moto / B. Subtilis) for roughly ten or fifteen dollars via eBay. Or if you know anyone who is Japanese ask them. In my case it was my Korean neighbours who gave it to me. They are such a wonderful couple. 

Friday, 15 August 2014

Prescript Assist for itchy bum (Proctitis)

I tried taking 4 x Prescript Assist probiotics the other night and Proctitis (itchy bum) was definitely greatly relieved. I would say an improvement of 90% or more, so it is quite a marked difference. I had tried just taking one or two before but that doesn't do anything noticeable for me. Looks like I need 3 or 4 of the pills at a time in order to get a therapeutic effect. 

There is a small chance it could also have possibly been all the chilli and fried onions I ate. This will gradually become clear with time. 

Prescript Assist is a unique brand of high quality probiotic. I was recommended this brand by Baruch who had also found that it helped with this problem. So credit goes to him :-D What's interesting about this brand is the wide selection of probiotic flora, beneficial flora that you rarely see in other probiotics, and also the high level of research and quality control from the manufacturer. If your in a medical or health professional then I definitely recommend looking into the company. 

Oh, and I note that this probiotic also contains B. Subtilis which is also found in Natto. And Natto is what I attribute my recent immune disorder remission to - I would prefer that you stick with Natto if you were looking for Ankylosing Spondylitis remission (AS). I'm just not sure if you will get enough of the B. Subtilis from this probiotic in order to help with AS. 


Sunday, 3 August 2014

Molecular Mimicry



Alan Ebringer - a trail blazer who researched the relationship between
diet, Klebsiella, and Ankylosing Spondylitis.

Video - Recovery from Ankylosing Spondylitis



Recovery from Ankylosing Spondylitis
A pretty good video about diet and AS
http://www.youtube.com/watch?v=qvgjJTLrM3M

Thursday, 24 July 2014

NSD Book Chapter

I have been working on this book chapter for Andrea that outlines my story, the diet I follow, a few recipes, and some other health info. Let me know if it helps you, or if you have any suggestions.

Here is the link:
https://docs.google.com/document/d/1-Vu4xEjJ3eknqi0-An7wgMtLdiOYi5SoL6xuo5X1L64/edit?usp=sharing


Homemade Eczema Cream (Vit B3 & Coconut oil)


Homemade Vit B3 Cream

This topical cream worked well for my eczema/dermatitis, but the cream I made is very strong and not suitable for sensitive parts of the body as it will sting. This is how I made it ..
Ingredients:
  • 1 part Glycerin (Glycerol) - can get this in any chemist. This helps dissolve the B3 and increases absorption 
  • 2 parts B3, crushed in a mortar & pestel - I used the niacinamide form of B3
  • 2 parts Virgin Coconut Oil, melted
Mix these together and place in a small glass or ceramic container. I suggest making another cream with a reduced concentration of B3 for sensitive areas (genitals, anus, face). It isn't quite as potent as the prednisolone creams but it does the job, and I prefer to use a vitamin rather than an immune suppressant. Always start by using a small amount on a small area of the body first as a test ..

Abstracts, Quotes, Etc

The quotes below are why I tried B3 (nicotinamide). Oh and found some other people were using coconut oil too..



This one shows that B3 can have an anti-inflammatory effect on the skin
http://en.wikipedia.org/wiki/Nicotinamide
Skin conditions
Nicotinamide has demonstrated anti-inflammatory actions that may be of benefit to patients with inflammatory skin conditions.[4] These conditions include acne vulgaris, and the compound can suppress antigen-induced, lymphocytic transformation and inhibit 3',5'-cyclic-AMP phosphodiesterase. Nicotinamide has demonstrated the ability to block the inflammatory actions of iodides known to precipitate or exacerbate inflammatory acne.
NicAzel and Nicomide are the names of oral acne medications that include nicotinamide as their most predominant ingredient, based on this area of research. Nicotinamide is also found as part of a new adjunct supplement combination called, AzerizinTM. According to the makers of Azerizin, this adjunct is part of their prescription dietary supplement product, which they claim helps manage inflammatory skin conditions. Nicotinamide is also used topically as a 4% or 5% gel or cream - as effective as topical 1% clindamycin (8-week double-blind trial) performed at the New York University College of Medicine.[5] Unlike topical Erythromycin or Clindamycin it does not precipitate bacterial resistance in treating inflammatory acne. Nicotinamide acne treatment is also available as Nicotinamide pads and cream.


This shows that B3 can the effectiveness of neutrophil immune cells by up to 1000 times in people who have a silenced/inactive gene
Title: C/EBPe mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice
The myeloid-specific transcription factor, CCAAT/enhancer-binding protein e (C/EBPe) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans, a condition that confers susceptibility to Staphylococcus aureus infection. We found that C/EBPe-deficient mice are severely affected by infection with S. aureus, and C/EBPe deficiency in neutrophils contributes to the infectious phenotype. Conversely, exposure to the epigenetic modulator nicotinamide (vitamin B3) increased expression of C/EBPe in WT myeloid cells. Further, nicotinamide increased the activity of C/EBPe and select downstream antimicrobial targets, particularly in neutrophils. In a systemic murine infection model as well as in murine and human peripheral blood, nicotinamide enhanced killing of S. aureus by up to 1,000 fold but had no effect when administered to either C/EBPe-deficient mice or mice depleted of neutrophils. Nicotinamide was efficacious in both prophylactic and therapeutic settings. Our findings suggest that C/EBPe is an important target to boost killing of bacteria by the innate immune system.

Also, if you look here there are good reports regarding topical use of coconut oil:


Safety

This safety note is really more targeted at people taking mega doses of Vit B3 orally, but may prove to be relevant if you use very large amounts of B3 Cream all over your body!


http://www.thedermreview.com/niacinamide/
Safety Issues
While niacinamide can be used to treat many different skin conditions, it should not be used by people with liver disease, patients with active ulcers or a history of ulcers, or anyone with gout. Also, if you drink excessive amounts of alcohol, you should abstain from using a niacinamide cream as it may react with the increased levels of alcohol in the body. Women who are pregnant or nursing should not consume more than 35 mg of niacin daily if taking a vitamin or a dietary supplement. Finally, if you use a niacinamide cream for the treatment of acne, dermatologists suggest that you start with a small amount of the cream on your skin so you can take note of any negative skin reactions. If you notice redness or peeling of the skin, you should discontinue use of the niacinamide cream and contact your skin care specialist.




Thursday, 10 July 2014

Did Natto bring my immune disorder into remission?

This week I stopped eating Natto to see if my eczema would clear, and unexpectedly my sensitivity to starch returned ! I had a full blown reaction after eating some hummus. Last night I started eating the Natto again and lo and behold my Ankylosing Spondylitis is calming down again. It is now about a tenth of what it was seven hours ago, normally it would take about 36 hours more for it to reduce this much.

So it looks like Natto is helping :D

Wednesday, 9 July 2014

Leaky gut soup?

A colleague at work recommended a soup for treating leaky gut. Basically you throw these things together and either slow cook them over a couple of hours, or use a pressure cooker:

  • Apple cider vinegar
  • Bones (beef bones)
  • Vegetables
  • Some protein - chicken was suggested
She will get back to me with some more detailed info on this..